PGT-SR : A healthy pregnancy is possible even after failed IVF Cycle, Recurrent Abortion or Advanced Age

Preimplantation genetic testing for structural chromosomal rearrangements (PGT-SR) is a specialized genetic testing procedure that is used to detect structural chromosomal rearrangements in embryos created through in-vitro fertilization (IVF) before they are implanted into the uterus. Structural chromosomal rearrangements are changes in the structure of chromosomes such as deletions, duplications, inversions, and translocations. These changes can affect the normal functioning of the genes and can lead to genetic disorders.

During PGT-SR, a small number of cells are removed from an embryo and analyzed for structural chromosomal rearrangements. This can be done by using techniques such as fluorescence in situ hybridization (FISH) or array comparative genomic hybridization (aCGH). This allows doctors to select the most viable and healthy embryos for implantation, increasing the chances of a successful pregnancy.

PGT-SR is recommended for couples 

  1. Multiple failed IVF cycles 
  2. Recurrent miscarriage
  3. Advanced reproductive age 
  4. Have a family history of structural chromosomal rearrangements, such as Down syndrome, Turner syndrome, and others. 

The benefits of PGT-SR include:

  • Identifying and avoiding the transfer of embryos with structural chromosomal rearrangements, which can lead to genetic disorders or miscarriage.
  • Improving the chances of having a healthy baby by selecting only unaffected embryos for transfer.
  • Reducing the need for invasive prenatal testing, such as amniocentesis, which carries a small risk of miscarriage.
  • Helping couples who have a history of recurrent miscarriage or who are at a high risk of having a baby with a genetic disorder to have a healthy pregnancy.
  • It can also help in cases of recurrent implantation failure or recurrent IVF failure.